Your vine is still a bit of a mystery to me, but I have one good possibility, Sicyos angulatus (One-seed burr cucumber). You can see more photos from Connecticut Botanical Society and here is more information from the University of Michigan's Plant Diversity Website and Illinois Wildflowers. None of these sites talks about it being a prickly threat to humans, but I can see how it might be if you encountered it while pushing through thick undergrowth.
Here are a few other prickly vines that you might run into (literally) in your area, but they don't match your description as well as the burr cucumber does. You should do your best to avoid contact with them, however!
Smilax bona-nox (Saw greenbrier)
Smilax tamnoides (Bristly greenbriar) and here are photos from Virginia Tech.
Smilax glauca (Cat greenbrier) and here are photos from University of Wisconsin's Freckmann Herbarium
Smilax rotundifolia (Roundleaf greenbrier) and here are photos.
Tragia cordata (Heartleaf noseburn) has stinging hairs on its stems and leaves but only grows to about 3 feet. It delivers a nasty sting, however, when you touch it. Here are photos from Missouri Plants.
Tragia urticifolia (Nettleleaf noseburn) is another short vine with stinging hairs. Here are photos from Missouri Plants.