Ask Mr. Smarty Plants

We could find no specific information for the possible toxicity of Parthenocissus heptaphylla (sevenleaf creeper).  However, we would recommend that you assume that it is poisonous since it is very closely related to Parthenocissus quinquefolia (Virginia creeper).  Because Sevenleaf creeper has a much smaller native range and is a much less well known species, there is simply not as much literature about it.  It's probable toxicity aside, Sevenleaf creeper makes a very fine pergola plant.  Another otherwise fine pergola plant is Wisteria frutescens (American wisteria).  Unfortunately, it and all members of its genus bear poisonous fruit.  Another nice pergola plant, Berchemia scandens (Alabama supplejack) also produces poisonous berries as does Bignonia capreolata (crossvine).  Are you noticing a pattern?  Many vines, for some reason, are poisonous.

Your best bet for a woody vine might be one of the native grapes that grow in your area.  While the fruit of Vitis mustangensis (mustang grape) is edible, you should not eat very many of them due to their high acid content which can burn the throat.  Other species, like Vitis monticola (sweet mountain grape) and Vitis cinerea var. helleri (Heller's grape) produce edible fruit on attractive vines.  A cousin of the grapes, Ampelopsis arborea (peppervine) produces edible, but not very tasty fruit.  However, it does make a very attractive pergola vine.